{"id":3615,"date":"2001-06-15T18:49:43","date_gmt":"2001-06-16T01:49:43","guid":{"rendered":"https:\/\/www.activator.com\/?p=3615"},"modified":"2023-06-07T08:32:00","modified_gmt":"2023-06-07T15:32:00","slug":"the-diagnostic-performance-of-vertebral-displacement-measurements-derived-from-ultrasonic-indentation-in-an-in-vivo-model-of-degenerative-disc-disease","status":"publish","type":"post","link":"https:\/\/activator.com\/the-diagnostic-performance-of-vertebral-displacement-measurements-derived-from-ultrasonic-indentation-in-an-in-vivo-model-of-degenerative-disc-disease\/","title":{"rendered":"The diagnostic performance of vertebral displacement measurements derived from ultrasonic indentation in an in vivo model of degenerative disc disease"},"content":{"rendered":"<h3>Abstract<\/h3>\n<h4>STUDY DESIGN:<\/h4>\n<p>The diagnostic performance of a newly described\u00a0 variable was assessed in an in vivo model of disc degeneration using a\u00a0 split-pair experimental design.<\/p>\n<h4>OBJECTIVE:<\/h4>\n<p>To determine if vertebral displacement measures\u00a0 generated from ultrasonic indentation could distinguish between\u00a0 experimental and control groups of animals.<\/p>\n<h4>SUMMARY OF BACKGROUND DATA:<\/h4>\n<p>Few procedures are available that\u00a0 noninvasively assess subcutaneous vertebral mechanics. Information from\u00a0 such a procedure would be of value in determining potential clinical\u00a0 relevance of spinal mechanics with respect to low back pain.<\/p>\n<h4>METHODS:<\/h4>\n<p>Eight adolescent pigs underwent endplate perforation\u00a0 surgery to initiate lumbar disc degeneration. After 4 months of\u00a0 recovery, these and eight age-matched controls were assessed by\u00a0 ultrasonic indentation, a noninvasive procedure that quantifies\u00a0 vertebral displacements in the plane of loading-indentation. Each animal\u00a0 then received a facetectomy and was reindented at the same location as\u00a0 confirmed by ultrasonic imaging. Discal materials were removed\u00a0 postmortem for analysis.<\/p>\n<h4>RESULTS:<\/h4>\n<p>Degenerative discs exhibited morphologic changes\u00a0 consistent with early degenerative disc disease. Prefacetectomy\u00a0 comparison of vertebral displacement measures between control and\u00a0 experimental animals resulted in sensitivity, specificity, and\u00a0 diagnostic accuracy values of 75.0%, 83.3%, and 77%, respectively. After\u00a0 facetectomy these values increased to 87.5%, 83.3%, and 85%,\u00a0 respectively. These measures of diagnostic performance were comparable\u00a0 or superior to those of existing clinical techniques (invasive or\u00a0 otherwise) used to assess degenerative conditions of the spine.<\/p>\n<h4>CONCLUSIONS:<\/h4>\n<p>The results of this study suggest that noninvasive\u00a0 measures of vertebral displacement are clinically significant and\u00a0 possess the additional advantages of being objective and noninvasive.<\/p>\n<hr \/>\n<p><a title=\"Spine.\" href=\"http:\/\/www.thespinejournalonline.com\/\" target=\"_blank\" rel=\"noopener\">Spine (Phila Pa 1976).<\/a> 2001 Jun 15;26(12):1348-55. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11426151\" target=\"_blank\" rel=\"noopener\">PMID:11426151<\/a>]<\/p>\n<p>Author information: Kawchuk GN, Kaigle AM, Holm SH, Rod Fauvel O, Ekstr\u00f6m L, Hansson T.\u00a0Department of Orthopaedics, Sahlgrenska University Hospital, G\u00f6teborg, Sweden.<\/p>\n<script>function getWR360PopupSkin(){return 'light_clean';}<\/script>","protected":false},"excerpt":{"rendered":"<p>Abstract STUDY DESIGN: The diagnostic performance of a newly described\u00a0 variable was assessed in an in vivo model of disc degeneration using a\u00a0 split-pair experimental design. OBJECTIVE: To determine if vertebral displacement measures\u00a0 generated from ultrasonic indentation could distinguish between\u00a0 experimental and control groups of animals. SUMMARY OF BACKGROUND DATA: Few procedures are available that\u00a0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[67,4],"tags":[238,239,240,241,242,243,244,160,113,45,68,225,245,246,226,227,178,228,247,77,248],"class_list":["post-3615","post","type-post","status-publish","format-standard","hentry","category-biomechanical","category-research","tag-animal","tag-bearing","tag-disease","tag-disk","tag-displacement","tag-fractures","tag-instability","tag-intervertebral","tag-joint","tag-lumbar","tag-mechanical","tag-models","tag-reproducibility","tag-results","tag-sensitivity","tag-specificity","tag-spinal","tag-stress","tag-swine","tag-vertebrae","tag-weight"],"acf":[],"_links":{"self":[{"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/posts\/3615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/comments?post=3615"}],"version-history":[{"count":1,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/posts\/3615\/revisions"}],"predecessor-version":[{"id":133732,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/posts\/3615\/revisions\/133732"}],"wp:attachment":[{"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/media?parent=3615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/categories?post=3615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/activator.com\/wp-json\/wp\/v2\/tags?post=3615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}